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Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy

Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management. Dantrolene is the specific antagonist of MH. The autho...

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Autores principales: Lapisatepun, Warangkana, Arkarattanakul, Supawan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057021/
https://www.ncbi.nlm.nih.gov/pubmed/32148968
http://dx.doi.org/10.1155/2020/6562896
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author Lapisatepun, Warangkana
Arkarattanakul, Supawan
author_facet Lapisatepun, Warangkana
Arkarattanakul, Supawan
author_sort Lapisatepun, Warangkana
collection PubMed
description Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management. Dantrolene is the specific antagonist of MH. The authors report the case of a 9-year-old boy who underwent an emergency bronchoscopy to remove a foreign body and developed masseter rigidity after succinylcholine and sevoflurane exposure. The anesthesia team diagnosed an MH event, and the event was managed immediately with supportive treatment, dantrolene, being administered within 10 minutes. The patient survived and had a good outcome without any complications. We suggest that it is essential for anesthesia providers to recognize the need for intraoperative vigilance, prompt recognition, and treatment, and dantrolene sodium should be readily available in every hospital.
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spelling pubmed-70570212020-03-06 Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy Lapisatepun, Warangkana Arkarattanakul, Supawan Case Rep Anesthesiol Case Report Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management. Dantrolene is the specific antagonist of MH. The authors report the case of a 9-year-old boy who underwent an emergency bronchoscopy to remove a foreign body and developed masseter rigidity after succinylcholine and sevoflurane exposure. The anesthesia team diagnosed an MH event, and the event was managed immediately with supportive treatment, dantrolene, being administered within 10 minutes. The patient survived and had a good outcome without any complications. We suggest that it is essential for anesthesia providers to recognize the need for intraoperative vigilance, prompt recognition, and treatment, and dantrolene sodium should be readily available in every hospital. Hindawi 2020-02-22 /pmc/articles/PMC7057021/ /pubmed/32148968 http://dx.doi.org/10.1155/2020/6562896 Text en Copyright © 2020 Warangkana Lapisatepun and Supawan Arkarattanakul. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lapisatepun, Warangkana
Arkarattanakul, Supawan
Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
title Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
title_full Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
title_fullStr Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
title_full_unstemmed Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
title_short Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
title_sort early recognition and treatment of malignant hyperthermia in pediatric patient during bronchoscopy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057021/
https://www.ncbi.nlm.nih.gov/pubmed/32148968
http://dx.doi.org/10.1155/2020/6562896
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