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Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

BACKGROUND: Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The leptin is one of the adipokines which presents in the serum in proportion to the amount of adipose tissue and is transl...

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Autores principales: Duan, De‐Min, Jhang, Jing‐Yi, Wu, Semon, Teng, Ming‐Sheng, Hsu, Lung‐An, Ko, Yu‐Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057123/
https://www.ncbi.nlm.nih.gov/pubmed/31914480
http://dx.doi.org/10.1002/mgg3.1113
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author Duan, De‐Min
Jhang, Jing‐Yi
Wu, Semon
Teng, Ming‐Sheng
Hsu, Lung‐An
Ko, Yu‐Lin
author_facet Duan, De‐Min
Jhang, Jing‐Yi
Wu, Semon
Teng, Ming‐Sheng
Hsu, Lung‐An
Ko, Yu‐Lin
author_sort Duan, De‐Min
collection PubMed
description BACKGROUND: Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The leptin is one of the adipokines which presents in the serum in proportion to the amount of adipose tissue and is translated from LEP gene. It involves in energy homeostasis, lipid and glucose metabolisms, modulation of immune systems, and thermogenesis. Many previous studies have revealed controversial results between LEP polymorphisms and leptin levels in different ages and ethnicities. Herein, we investigated the impacts of LEP polymorphism against leptin levels in Taiwanese subjects. METHODS: In 599 Taiwanese subjects, excluding clinically overt systemic disease, age below 18 years old, and C‐reactive protein (CRP) level of above 10 mg/L, few of LEP polymorphisms were genotyped with TaqMan SNP genotyping assays, were further analyzed for association with leptin level in univariate and multivariate linear regression analyses with Bonferroni correction for multiple tests in stratified groups. The univariate and stepwise multivariate linear regression analyses were performed to determine the coefficient of determinant of LEP polymorphisms over leptin level. RESULTS: Significant associations were found between LEP polymorphisms and leptin levels in obese women. Circulating leptin level was positively correlated with inflammatory, insulin resistance markers, and visceral obesity markers in all subjects. Furthermore, stratified and interaction analyses revealed that LEP polymorphisms, rs7799039 and rs2167270, were significantly associated with leptin levels in obese women—8%–10% of which could be explained by LEP polymorphisms. CONCLUSION: The LEP polymorphisms are independently associated with leptin levels in Taiwanese obese women. Further, the genetic determinants for leptin levels may be different between obese and nonobese, and in different sex individuals. The obesity status and female sex may exert modification effect on transcription of LEP, particularly in obese women.
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spelling pubmed-70571232020-03-12 Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women Duan, De‐Min Jhang, Jing‐Yi Wu, Semon Teng, Ming‐Sheng Hsu, Lung‐An Ko, Yu‐Lin Mol Genet Genomic Med Original Articles BACKGROUND: Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The leptin is one of the adipokines which presents in the serum in proportion to the amount of adipose tissue and is translated from LEP gene. It involves in energy homeostasis, lipid and glucose metabolisms, modulation of immune systems, and thermogenesis. Many previous studies have revealed controversial results between LEP polymorphisms and leptin levels in different ages and ethnicities. Herein, we investigated the impacts of LEP polymorphism against leptin levels in Taiwanese subjects. METHODS: In 599 Taiwanese subjects, excluding clinically overt systemic disease, age below 18 years old, and C‐reactive protein (CRP) level of above 10 mg/L, few of LEP polymorphisms were genotyped with TaqMan SNP genotyping assays, were further analyzed for association with leptin level in univariate and multivariate linear regression analyses with Bonferroni correction for multiple tests in stratified groups. The univariate and stepwise multivariate linear regression analyses were performed to determine the coefficient of determinant of LEP polymorphisms over leptin level. RESULTS: Significant associations were found between LEP polymorphisms and leptin levels in obese women. Circulating leptin level was positively correlated with inflammatory, insulin resistance markers, and visceral obesity markers in all subjects. Furthermore, stratified and interaction analyses revealed that LEP polymorphisms, rs7799039 and rs2167270, were significantly associated with leptin levels in obese women—8%–10% of which could be explained by LEP polymorphisms. CONCLUSION: The LEP polymorphisms are independently associated with leptin levels in Taiwanese obese women. Further, the genetic determinants for leptin levels may be different between obese and nonobese, and in different sex individuals. The obesity status and female sex may exert modification effect on transcription of LEP, particularly in obese women. John Wiley and Sons Inc. 2020-01-08 /pmc/articles/PMC7057123/ /pubmed/31914480 http://dx.doi.org/10.1002/mgg3.1113 Text en © 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Duan, De‐Min
Jhang, Jing‐Yi
Wu, Semon
Teng, Ming‐Sheng
Hsu, Lung‐An
Ko, Yu‐Lin
Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women
title Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women
title_full Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women
title_fullStr Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women
title_full_unstemmed Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women
title_short Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women
title_sort modification effect of sex and obesity on the correlation of lep polymorphisms with leptin levels in taiwanese obese women
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057123/
https://www.ncbi.nlm.nih.gov/pubmed/31914480
http://dx.doi.org/10.1002/mgg3.1113
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