DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ

Diacylglycerol kinase γ (DGKγ) regulates protein kinase C (PKC) activity by converting DG to phosphatidic acid (PA). DGKγ directly interacts with PKCγ and is phosphorylated by PKCγ, resulting in the upregulation of lipid kinase activity. PKC dysfunction impairs motor coordination, indicating that th...

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Detalles Bibliográficos
Autores principales: Tsumagari, Ryosuke, Kakizawa, Sho, Kikunaga, Sakiko, Fujihara, Yoshitaka, Ueda, Shuji, Yamanoue, Minoru, Saito, Naoaki, Ikawa, Masahito, Shirai, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057140/
https://www.ncbi.nlm.nih.gov/pubmed/32033984
http://dx.doi.org/10.1523/ENEURO.0319-19.2020

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