TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling

BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient TGF-β signaling, through its role in stabilizing the TGFBR1 and TGFBR2 complex. Here we demonstrate that TGFBR2 phosphorylates BUB1 at Serine-318, which is conserved in primates. S318 phosphorylation abrogates the interaction o...

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Detalles Bibliográficos
Autores principales: Nyati, Shyam, Gregg, Brandon S., Xu, Jiaqi, Young, Grant, Kimmel, Lauren, Nyati, Mukesh K., Ray, Dipankar, Speers, Corey, Rehemtulla, Alnawaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057164/
https://www.ncbi.nlm.nih.gov/pubmed/32143140
http://dx.doi.org/10.1016/j.neo.2020.02.001

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