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Role of Descending Dopaminergic Pathways in Pain Modulation
Abstract: Pain, especially when chronic, is a common reason patients seek medical care and it affects the quality of life and well-being of the patients. Unfortunately, currently available therapies for chronic pain are often inadequate because the neu-robiological basis of such pain is still not fu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057207/ https://www.ncbi.nlm.nih.gov/pubmed/31182003 http://dx.doi.org/10.2174/1570159X17666190430102531 |
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author | Li, Changsheng Liu, Sufang Lu, Xihua Tao, Feng |
author_facet | Li, Changsheng Liu, Sufang Lu, Xihua Tao, Feng |
author_sort | Li, Changsheng |
collection | PubMed |
description | Abstract: Pain, especially when chronic, is a common reason patients seek medical care and it affects the quality of life and well-being of the patients. Unfortunately, currently available therapies for chronic pain are often inadequate because the neu-robiological basis of such pain is still not fully understood. Although dopamine has been known as a neurotransmitter to mediate reward and motivation, accumulating evidence has shown that dopamine systems in the brain are also involved in the central regulation of chronic pain. Most importantly, descending dopaminergic pathways play an important role in pain mod-ulation. In this review, we discuss dopamine receptors, dopaminergic systems in the brain, and the role of descending dopa-minergic pathways in the modulation of different types of pain. |
format | Online Article Text |
id | pubmed-7057207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-70572072020-06-01 Role of Descending Dopaminergic Pathways in Pain Modulation Li, Changsheng Liu, Sufang Lu, Xihua Tao, Feng Curr Neuropharmacol Article Abstract: Pain, especially when chronic, is a common reason patients seek medical care and it affects the quality of life and well-being of the patients. Unfortunately, currently available therapies for chronic pain are often inadequate because the neu-robiological basis of such pain is still not fully understood. Although dopamine has been known as a neurotransmitter to mediate reward and motivation, accumulating evidence has shown that dopamine systems in the brain are also involved in the central regulation of chronic pain. Most importantly, descending dopaminergic pathways play an important role in pain mod-ulation. In this review, we discuss dopamine receptors, dopaminergic systems in the brain, and the role of descending dopa-minergic pathways in the modulation of different types of pain. Bentham Science Publishers 2019-12 2019-12 /pmc/articles/PMC7057207/ /pubmed/31182003 http://dx.doi.org/10.2174/1570159X17666190430102531 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Li, Changsheng Liu, Sufang Lu, Xihua Tao, Feng Role of Descending Dopaminergic Pathways in Pain Modulation |
title | Role of Descending Dopaminergic Pathways in Pain Modulation |
title_full | Role of Descending Dopaminergic Pathways in Pain Modulation |
title_fullStr | Role of Descending Dopaminergic Pathways in Pain Modulation |
title_full_unstemmed | Role of Descending Dopaminergic Pathways in Pain Modulation |
title_short | Role of Descending Dopaminergic Pathways in Pain Modulation |
title_sort | role of descending dopaminergic pathways in pain modulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057207/ https://www.ncbi.nlm.nih.gov/pubmed/31182003 http://dx.doi.org/10.2174/1570159X17666190430102531 |
work_keys_str_mv | AT lichangsheng roleofdescendingdopaminergicpathwaysinpainmodulation AT liusufang roleofdescendingdopaminergicpathwaysinpainmodulation AT luxihua roleofdescendingdopaminergicpathwaysinpainmodulation AT taofeng roleofdescendingdopaminergicpathwaysinpainmodulation |