Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for thera...

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Detalles Bibliográficos
Autores principales: Mitropoulou, Alkistis N., Ceska, Tom, Heads, James T., Beavil, Andrew J., Henry, Alistair J., McDonnell, James M., Sutton, Brian J., Davies, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057348/
https://www.ncbi.nlm.nih.gov/pubmed/32133997
http://dx.doi.org/10.1107/S2053230X20001466

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