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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes

BACKGROUND: Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human primary T cells. Nonetheless, for patients w...

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Detalles Bibliográficos
Autores principales:	Marotte, Lucine, Simon, Sylvain, Vignard, Virginie, Dupre, Emilie, Gantier, Malika, Cruard, Jonathan, Alberge, Jean-Baptiste, Hussong, Melanie, Deleine, Cecile, Heslan, Jean-Marie, Shaffer, Jonathan, Beauvais, Tiffany, Gaschet, Joelle, Scotet, Emmanuel, Fradin, Delphine, Jarry, Anne, Nguyen, Tuan, Labarriere, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057432/ https://www.ncbi.nlm.nih.gov/pubmed/32001504 http://dx.doi.org/10.1136/jitc-2019-000311

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