Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Insoluble intracellular aggregation of tau proteins into filaments and neurodegeneration are histopathological hallmarks of Alzheimer disease (AD) and other tauopathies. Recently, prefibrillar, soluble, oligomeric tau intermediates have emerged as relevant pathological tau species; however, the mole...

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Detalles Bibliográficos
Autores principales: Zheng, Jin, Akbari, Mansour, Schirmer, Claire, Reynaert, Marie-Line, Loyens, Anne, Lefebvre, Bruno, Buée, Luc, Croteau, Deborah L., Galas, Marie-Christine, Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057491/
https://www.ncbi.nlm.nih.gov/pubmed/32131898
http://dx.doi.org/10.1186/s40478-020-00896-8

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