PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

BACKGROUND: Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling evidence to causatively link specific PINK1/parkin depend...

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Detalles Bibliográficos
Autores principales: Pirooznia, Sheila K., Yuan, Changqing, Khan, Mohammed Repon, Karuppagounder, Senthilkumar S., Wang, Luan, Xiong, Yulan, Kang, Sung Ung, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057660/
https://www.ncbi.nlm.nih.gov/pubmed/32138754
http://dx.doi.org/10.1186/s13024-020-00363-x

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