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Microsecond Simulation of the Proteoglycan-like Region of Carbonic Anhydrase IX and Design of Chemical Inhibitors Targeting pH Homeostasis in Cancer Cells

[Image: see text] Carbonic anhydrase IX (CAIX) is a membrane-bound enzyme associated with tumor hypoxia and found to be over expressed in various tumor conditions. Targeting CAIX catalytic activity is proven to be efficient modality in modulating pH homeostasis in cancer cells. Proteoglycan-like (PG...

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Detalles Bibliográficos
Autores principales:	John, Arun, Vetrivel, Umashankar, Sivashanmugam, Muthukumaran, Natarajan, Sulochana Konerirajapuram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057697/ https://www.ncbi.nlm.nih.gov/pubmed/32149257 http://dx.doi.org/10.1021/acsomega.9b04203

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