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Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β-cells causes morphological and functional changes

Diabetes mellitus is a metabolic disorder predominantly caused by the dysfunction of pancreatic β-cells. This dysfunction is partly caused by the dysregulation of pyruvate dehydrogenase (PDH), which acts as an important mediator of pyruvate oxidation after glycolysis and fuels the tricarboxylic acid...

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Detalles Bibliográficos
Autores principales:	Wang, Xiao, Lai, Shuchang, Ye, Yanshi, Hu, Yuanyuan, Pan, Daoyan, Bai, Xiaochun, Shen, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057776/ https://www.ncbi.nlm.nih.gov/pubmed/32319629 http://dx.doi.org/10.3892/mmr.2020.10993

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