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Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
CONTEXT: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. AIMS: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracran...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057881/ https://www.ncbi.nlm.nih.gov/pubmed/32181170 http://dx.doi.org/10.4103/ajns.AJNS_351_19 |
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author | Kaewborisutsakul, Anukoon Tunthanathip, Thara Yuwakosol, Pakorn Inkate, Srirat Pattharachayakul, Sutthiporn |
author_facet | Kaewborisutsakul, Anukoon Tunthanathip, Thara Yuwakosol, Pakorn Inkate, Srirat Pattharachayakul, Sutthiporn |
author_sort | Kaewborisutsakul, Anukoon |
collection | PubMed |
description | CONTEXT: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. AIMS: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracranial tumors. SETTING AND DESIGNS: This was a retrospective cohort study. METHODS: Data from the institutional database (between January 2017 and December 2018) were reviewed. Consecutive patients with intracranial tumors who underwent craniotomy were included. STATISTICAL ANALYSIS USED: Patient characteristics were reported as descriptive data, and factors associated with VTE development were analyzed by the Cox regression model. RESULTS: The study identified 177 patients. The incidence of VTE was 10.2% (deep-vein thrombosis [DVT], 8.5%; pulmonary embolism [PE] 1.7%; and simultaneous DVT and PE, 1.7%). In univariate analysis, VTE development was associated with diabetes mellitus (DM), operative duration of >420 min, blood transfusion, and new-onset postoperative motor deficits. DM and new-onset postoperative motor deficits were statistically significant factors in multivariable analysis, with hazard ratios of 4.52 (95% confidence interval [CI] = 1.38–14.82) and 3.46 (95% CI = 1.17–10.23), respectively. CONCLUSIONS: Postcraniotomy VTE was detected in 10.2% of patients with intracranial tumors. Risk factors for VTE included DM and new-onset postoperative motor deficits. Hence, intracranial tumor patients with these risk factors are the most likely to require VTE prophylaxis with an anticoagulant. |
format | Online Article Text |
id | pubmed-7057881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-70578812020-03-16 Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study Kaewborisutsakul, Anukoon Tunthanathip, Thara Yuwakosol, Pakorn Inkate, Srirat Pattharachayakul, Sutthiporn Asian J Neurosurg Original Article CONTEXT: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. AIMS: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracranial tumors. SETTING AND DESIGNS: This was a retrospective cohort study. METHODS: Data from the institutional database (between January 2017 and December 2018) were reviewed. Consecutive patients with intracranial tumors who underwent craniotomy were included. STATISTICAL ANALYSIS USED: Patient characteristics were reported as descriptive data, and factors associated with VTE development were analyzed by the Cox regression model. RESULTS: The study identified 177 patients. The incidence of VTE was 10.2% (deep-vein thrombosis [DVT], 8.5%; pulmonary embolism [PE] 1.7%; and simultaneous DVT and PE, 1.7%). In univariate analysis, VTE development was associated with diabetes mellitus (DM), operative duration of >420 min, blood transfusion, and new-onset postoperative motor deficits. DM and new-onset postoperative motor deficits were statistically significant factors in multivariable analysis, with hazard ratios of 4.52 (95% confidence interval [CI] = 1.38–14.82) and 3.46 (95% CI = 1.17–10.23), respectively. CONCLUSIONS: Postcraniotomy VTE was detected in 10.2% of patients with intracranial tumors. Risk factors for VTE included DM and new-onset postoperative motor deficits. Hence, intracranial tumor patients with these risk factors are the most likely to require VTE prophylaxis with an anticoagulant. Wolters Kluwer - Medknow 2020-02-25 /pmc/articles/PMC7057881/ /pubmed/32181170 http://dx.doi.org/10.4103/ajns.AJNS_351_19 Text en Copyright: © 2020 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kaewborisutsakul, Anukoon Tunthanathip, Thara Yuwakosol, Pakorn Inkate, Srirat Pattharachayakul, Sutthiporn Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study |
title | Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study |
title_full | Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study |
title_fullStr | Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study |
title_full_unstemmed | Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study |
title_short | Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study |
title_sort | incidence and risk factors for venous thromboembolism following craniotomy for intracranial tumors: a cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057881/ https://www.ncbi.nlm.nih.gov/pubmed/32181170 http://dx.doi.org/10.4103/ajns.AJNS_351_19 |
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