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Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study

CONTEXT: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. AIMS: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracran...

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Autores principales: Kaewborisutsakul, Anukoon, Tunthanathip, Thara, Yuwakosol, Pakorn, Inkate, Srirat, Pattharachayakul, Sutthiporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057881/
https://www.ncbi.nlm.nih.gov/pubmed/32181170
http://dx.doi.org/10.4103/ajns.AJNS_351_19
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author Kaewborisutsakul, Anukoon
Tunthanathip, Thara
Yuwakosol, Pakorn
Inkate, Srirat
Pattharachayakul, Sutthiporn
author_facet Kaewborisutsakul, Anukoon
Tunthanathip, Thara
Yuwakosol, Pakorn
Inkate, Srirat
Pattharachayakul, Sutthiporn
author_sort Kaewborisutsakul, Anukoon
collection PubMed
description CONTEXT: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. AIMS: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracranial tumors. SETTING AND DESIGNS: This was a retrospective cohort study. METHODS: Data from the institutional database (between January 2017 and December 2018) were reviewed. Consecutive patients with intracranial tumors who underwent craniotomy were included. STATISTICAL ANALYSIS USED: Patient characteristics were reported as descriptive data, and factors associated with VTE development were analyzed by the Cox regression model. RESULTS: The study identified 177 patients. The incidence of VTE was 10.2% (deep-vein thrombosis [DVT], 8.5%; pulmonary embolism [PE] 1.7%; and simultaneous DVT and PE, 1.7%). In univariate analysis, VTE development was associated with diabetes mellitus (DM), operative duration of >420 min, blood transfusion, and new-onset postoperative motor deficits. DM and new-onset postoperative motor deficits were statistically significant factors in multivariable analysis, with hazard ratios of 4.52 (95% confidence interval [CI] = 1.38–14.82) and 3.46 (95% CI = 1.17–10.23), respectively. CONCLUSIONS: Postcraniotomy VTE was detected in 10.2% of patients with intracranial tumors. Risk factors for VTE included DM and new-onset postoperative motor deficits. Hence, intracranial tumor patients with these risk factors are the most likely to require VTE prophylaxis with an anticoagulant.
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spelling pubmed-70578812020-03-16 Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study Kaewborisutsakul, Anukoon Tunthanathip, Thara Yuwakosol, Pakorn Inkate, Srirat Pattharachayakul, Sutthiporn Asian J Neurosurg Original Article CONTEXT: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. AIMS: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracranial tumors. SETTING AND DESIGNS: This was a retrospective cohort study. METHODS: Data from the institutional database (between January 2017 and December 2018) were reviewed. Consecutive patients with intracranial tumors who underwent craniotomy were included. STATISTICAL ANALYSIS USED: Patient characteristics were reported as descriptive data, and factors associated with VTE development were analyzed by the Cox regression model. RESULTS: The study identified 177 patients. The incidence of VTE was 10.2% (deep-vein thrombosis [DVT], 8.5%; pulmonary embolism [PE] 1.7%; and simultaneous DVT and PE, 1.7%). In univariate analysis, VTE development was associated with diabetes mellitus (DM), operative duration of >420 min, blood transfusion, and new-onset postoperative motor deficits. DM and new-onset postoperative motor deficits were statistically significant factors in multivariable analysis, with hazard ratios of 4.52 (95% confidence interval [CI] = 1.38–14.82) and 3.46 (95% CI = 1.17–10.23), respectively. CONCLUSIONS: Postcraniotomy VTE was detected in 10.2% of patients with intracranial tumors. Risk factors for VTE included DM and new-onset postoperative motor deficits. Hence, intracranial tumor patients with these risk factors are the most likely to require VTE prophylaxis with an anticoagulant. Wolters Kluwer - Medknow 2020-02-25 /pmc/articles/PMC7057881/ /pubmed/32181170 http://dx.doi.org/10.4103/ajns.AJNS_351_19 Text en Copyright: © 2020 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kaewborisutsakul, Anukoon
Tunthanathip, Thara
Yuwakosol, Pakorn
Inkate, Srirat
Pattharachayakul, Sutthiporn
Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
title Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
title_full Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
title_fullStr Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
title_full_unstemmed Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
title_short Incidence and Risk Factors for Venous Thromboembolism Following Craniotomy for Intracranial Tumors: A Cohort Study
title_sort incidence and risk factors for venous thromboembolism following craniotomy for intracranial tumors: a cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057881/
https://www.ncbi.nlm.nih.gov/pubmed/32181170
http://dx.doi.org/10.4103/ajns.AJNS_351_19
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