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Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male

Merkel cell carcinoma is a cutaneous neuroendocrine malignancy that has an aggressive nature. Classically, it affects the elderly Caucasian population with a predilection for the sun-exposed areas of the body. Pathogenesis has been linked to ultraviolet radiation, immunosuppression, and the Merkel c...

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Autores principales: Jockisch, Kalah, Abdeen, Yazan, Alderink, Carlisle, Flippin, Tony, Kuru, Sugabramya, Shaaban, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057882/
https://www.ncbi.nlm.nih.gov/pubmed/32181186
http://dx.doi.org/10.4103/ajns.AJNS_5_18
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author Jockisch, Kalah
Abdeen, Yazan
Alderink, Carlisle
Flippin, Tony
Kuru, Sugabramya
Shaaban, Hamid
author_facet Jockisch, Kalah
Abdeen, Yazan
Alderink, Carlisle
Flippin, Tony
Kuru, Sugabramya
Shaaban, Hamid
author_sort Jockisch, Kalah
collection PubMed
description Merkel cell carcinoma is a cutaneous neuroendocrine malignancy that has an aggressive nature. Classically, it affects the elderly Caucasian population with a predilection for the sun-exposed areas of the body. Pathogenesis has been linked to ultraviolet radiation, immunosuppression, and the Merkel cell polyomavirus. Definitive diagnosis entails histologic evaluation and immunohistochemical staining. With its generalized appearance and tendency for metastasis, a high index of suspicion must be utilized. In this case, we present the unique presentation of Merkel cell carcinoma as a rapidly enlarging lymph node with metastatic disease to the spinal column presenting as new-onset low back and radicular pain.
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spelling pubmed-70578822020-03-16 Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male Jockisch, Kalah Abdeen, Yazan Alderink, Carlisle Flippin, Tony Kuru, Sugabramya Shaaban, Hamid Asian J Neurosurg Case Report Merkel cell carcinoma is a cutaneous neuroendocrine malignancy that has an aggressive nature. Classically, it affects the elderly Caucasian population with a predilection for the sun-exposed areas of the body. Pathogenesis has been linked to ultraviolet radiation, immunosuppression, and the Merkel cell polyomavirus. Definitive diagnosis entails histologic evaluation and immunohistochemical staining. With its generalized appearance and tendency for metastasis, a high index of suspicion must be utilized. In this case, we present the unique presentation of Merkel cell carcinoma as a rapidly enlarging lymph node with metastatic disease to the spinal column presenting as new-onset low back and radicular pain. Wolters Kluwer - Medknow 2020-02-25 /pmc/articles/PMC7057882/ /pubmed/32181186 http://dx.doi.org/10.4103/ajns.AJNS_5_18 Text en Copyright: © 2020 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Jockisch, Kalah
Abdeen, Yazan
Alderink, Carlisle
Flippin, Tony
Kuru, Sugabramya
Shaaban, Hamid
Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
title Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
title_full Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
title_fullStr Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
title_full_unstemmed Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
title_short Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
title_sort spinal metastasis from merkel cell carcinoma in an elderly male
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057882/
https://www.ncbi.nlm.nih.gov/pubmed/32181186
http://dx.doi.org/10.4103/ajns.AJNS_5_18
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