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Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male
Merkel cell carcinoma is a cutaneous neuroendocrine malignancy that has an aggressive nature. Classically, it affects the elderly Caucasian population with a predilection for the sun-exposed areas of the body. Pathogenesis has been linked to ultraviolet radiation, immunosuppression, and the Merkel c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057882/ https://www.ncbi.nlm.nih.gov/pubmed/32181186 http://dx.doi.org/10.4103/ajns.AJNS_5_18 |
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author | Jockisch, Kalah Abdeen, Yazan Alderink, Carlisle Flippin, Tony Kuru, Sugabramya Shaaban, Hamid |
author_facet | Jockisch, Kalah Abdeen, Yazan Alderink, Carlisle Flippin, Tony Kuru, Sugabramya Shaaban, Hamid |
author_sort | Jockisch, Kalah |
collection | PubMed |
description | Merkel cell carcinoma is a cutaneous neuroendocrine malignancy that has an aggressive nature. Classically, it affects the elderly Caucasian population with a predilection for the sun-exposed areas of the body. Pathogenesis has been linked to ultraviolet radiation, immunosuppression, and the Merkel cell polyomavirus. Definitive diagnosis entails histologic evaluation and immunohistochemical staining. With its generalized appearance and tendency for metastasis, a high index of suspicion must be utilized. In this case, we present the unique presentation of Merkel cell carcinoma as a rapidly enlarging lymph node with metastatic disease to the spinal column presenting as new-onset low back and radicular pain. |
format | Online Article Text |
id | pubmed-7057882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-70578822020-03-16 Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male Jockisch, Kalah Abdeen, Yazan Alderink, Carlisle Flippin, Tony Kuru, Sugabramya Shaaban, Hamid Asian J Neurosurg Case Report Merkel cell carcinoma is a cutaneous neuroendocrine malignancy that has an aggressive nature. Classically, it affects the elderly Caucasian population with a predilection for the sun-exposed areas of the body. Pathogenesis has been linked to ultraviolet radiation, immunosuppression, and the Merkel cell polyomavirus. Definitive diagnosis entails histologic evaluation and immunohistochemical staining. With its generalized appearance and tendency for metastasis, a high index of suspicion must be utilized. In this case, we present the unique presentation of Merkel cell carcinoma as a rapidly enlarging lymph node with metastatic disease to the spinal column presenting as new-onset low back and radicular pain. Wolters Kluwer - Medknow 2020-02-25 /pmc/articles/PMC7057882/ /pubmed/32181186 http://dx.doi.org/10.4103/ajns.AJNS_5_18 Text en Copyright: © 2020 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Jockisch, Kalah Abdeen, Yazan Alderink, Carlisle Flippin, Tony Kuru, Sugabramya Shaaban, Hamid Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male |
title | Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male |
title_full | Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male |
title_fullStr | Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male |
title_full_unstemmed | Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male |
title_short | Spinal Metastasis from Merkel Cell Carcinoma in an Elderly Male |
title_sort | spinal metastasis from merkel cell carcinoma in an elderly male |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057882/ https://www.ncbi.nlm.nih.gov/pubmed/32181186 http://dx.doi.org/10.4103/ajns.AJNS_5_18 |
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