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Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
To tackle the global antibiotic resistance crisis, antibiotic resistance acquired either vertically by chromosomal mutations or horizontally through antibiotic resistance genes (ARGs) have been studied. Yet, little is known about the interactions between the two, which may impact the evolution of an...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057998/ https://www.ncbi.nlm.nih.gov/pubmed/32139686 http://dx.doi.org/10.1038/s41467-020-15080-8 |