Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy

Mutations to the gene encoding superoxide dismutase-1 (SOD1) were the first genetic elements discovered that cause motor neuron disease (MND). These mutations result in compromised SOD1 dimer stability, with one of the severest and most common mutations Ala4Val (A4V) displaying a propensity to monom...

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Detalles Bibliográficos
Autores principales: Chantadul, Varunya, Wright, Gareth S. A., Amporndanai, Kangsa, Shahid, Munazza, Antonyuk, Svetlana V., Washbourn, Gina, Rogers, Michael, Roberts, Natalie, Pye, Matthew, O’Neill, Paul M., Hasnain, S. Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058017/
https://www.ncbi.nlm.nih.gov/pubmed/32139772
http://dx.doi.org/10.1038/s42003-020-0826-3

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