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Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience
Although the introduction of immunotherapy has improved outcomes for follicular lymphoma (FL) patients, histological transformation (HT) and early relapse still confer a poor prognosis. We sought to describe the patterns of change in treatment, response, and outcome of FL patients at our institution...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058022/ https://www.ncbi.nlm.nih.gov/pubmed/32139690 http://dx.doi.org/10.1038/s41408-020-0299-0 |
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author | Mozas, Pablo Nadeu, Ferran Rivas-Delgado, Alfredo Rivero, Andrea Garrote, Marta Balagué, Olga González-Farré, Blanca Veloza, Luis Baumann, Tycho Giné, Eva Delgado, Julio Villamor, Neus Campo, Elías Magnano, Laura López-Guillermo, Armando |
author_facet | Mozas, Pablo Nadeu, Ferran Rivas-Delgado, Alfredo Rivero, Andrea Garrote, Marta Balagué, Olga González-Farré, Blanca Veloza, Luis Baumann, Tycho Giné, Eva Delgado, Julio Villamor, Neus Campo, Elías Magnano, Laura López-Guillermo, Armando |
author_sort | Mozas, Pablo |
collection | PubMed |
description | Although the introduction of immunotherapy has improved outcomes for follicular lymphoma (FL) patients, histological transformation (HT) and early relapse still confer a poor prognosis. We sought to describe the patterns of change in treatment, response, and outcome of FL patients at our institution over the last four decades. Seven hundred and twenty-seven patients (389 F/338 M; median age, 57 years) consecutively diagnosed with grade 1-3a FL between 1980 and 2017, categorized into four decades according to the time of diagnosis, constituted the study population. Clinical characteristics, treatment, response, absolute and relative survival, HT, second malignancies (SM), and causes of death were assessed. Median OS for the entire cohort was 17.6 years. From decade 1 to 4, there was an increase in the complete response rate (48 to 70%), progression-free survival (40 to 56% at 5 years), OS (77 to 86% at 5 years), and relative survival ratio (0.83 to 0.94 at 5 years), with no significant differences in the risk of HT or SM. Lymphoma remained the most common cause of death in all four decades. These findings illustrate the overall improvement in outcome for FL patients, but support the need for further research into risk stratification and management. |
format | Online Article Text |
id | pubmed-7058022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70580222020-03-19 Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience Mozas, Pablo Nadeu, Ferran Rivas-Delgado, Alfredo Rivero, Andrea Garrote, Marta Balagué, Olga González-Farré, Blanca Veloza, Luis Baumann, Tycho Giné, Eva Delgado, Julio Villamor, Neus Campo, Elías Magnano, Laura López-Guillermo, Armando Blood Cancer J Article Although the introduction of immunotherapy has improved outcomes for follicular lymphoma (FL) patients, histological transformation (HT) and early relapse still confer a poor prognosis. We sought to describe the patterns of change in treatment, response, and outcome of FL patients at our institution over the last four decades. Seven hundred and twenty-seven patients (389 F/338 M; median age, 57 years) consecutively diagnosed with grade 1-3a FL between 1980 and 2017, categorized into four decades according to the time of diagnosis, constituted the study population. Clinical characteristics, treatment, response, absolute and relative survival, HT, second malignancies (SM), and causes of death were assessed. Median OS for the entire cohort was 17.6 years. From decade 1 to 4, there was an increase in the complete response rate (48 to 70%), progression-free survival (40 to 56% at 5 years), OS (77 to 86% at 5 years), and relative survival ratio (0.83 to 0.94 at 5 years), with no significant differences in the risk of HT or SM. Lymphoma remained the most common cause of death in all four decades. These findings illustrate the overall improvement in outcome for FL patients, but support the need for further research into risk stratification and management. Nature Publishing Group UK 2020-03-05 /pmc/articles/PMC7058022/ /pubmed/32139690 http://dx.doi.org/10.1038/s41408-020-0299-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mozas, Pablo Nadeu, Ferran Rivas-Delgado, Alfredo Rivero, Andrea Garrote, Marta Balagué, Olga González-Farré, Blanca Veloza, Luis Baumann, Tycho Giné, Eva Delgado, Julio Villamor, Neus Campo, Elías Magnano, Laura López-Guillermo, Armando Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
title | Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
title_full | Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
title_fullStr | Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
title_full_unstemmed | Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
title_short | Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
title_sort | patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058022/ https://www.ncbi.nlm.nih.gov/pubmed/32139690 http://dx.doi.org/10.1038/s41408-020-0299-0 |
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