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Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat
The retrosplenial cortex forms part of a network of cortical and subcortical structures that have particular importance for spatial learning and navigation in rodents. This study examined how retrosplenial lesions affect activity in this network by visualising the expression of the immediate-early g...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058225/ https://www.ncbi.nlm.nih.gov/pubmed/32166157 http://dx.doi.org/10.1177/2398212818811235 |
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author | Powell, Anna L Hindley, Emma Nelson, Andrew JD Davies, Moira Amin, Eman Aggleton, John P Vann, Seralynne D |
author_facet | Powell, Anna L Hindley, Emma Nelson, Andrew JD Davies, Moira Amin, Eman Aggleton, John P Vann, Seralynne D |
author_sort | Powell, Anna L |
collection | PubMed |
description | The retrosplenial cortex forms part of a network of cortical and subcortical structures that have particular importance for spatial learning and navigation in rodents. This study examined how retrosplenial lesions affect activity in this network by visualising the expression of the immediate-early genes c-fos and zif268 after exposure to a novel location. Groups of rats with extensive cytotoxic lesions (areas 29 and 30) and rats with lesions largely confined to area 30 (dysgranular cortex) were compared with their respective control animals for levels of c-fos expression measured by immunohistochemistry. These cortical lesions had very limited effects on distal c-fos activity. Evidence of a restricted reduction in c-fos activity was seen in the septal dentate gyrus (superior blade) but not in other hippocampal and parahippocampal subareas, nor in the anterior cingulate and prelimbic cortices. Related studies examined zif268 activity in those cases with combined area 29 and 30 lesions. The only clear evidence for reduced zif268 activity following retrosplenial cell loss came from the septal CA3 area. The confined impact of retrosplenial tissue loss is notable as, by the same immediate-early gene measures, retrosplenial cortex is itself highly sensitive to damage in related limbic areas, showing a marked c-fos and zif268 hypoactivity across all of its subareas. This asymmetry in covert pathology may help to explain the apparent disparity between the severity of learning deficits after retrosplenial cortex lesions and after lesions in either the hippocampus or the anterior thalamic nuclei. |
format | Online Article Text |
id | pubmed-7058225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-70582252020-03-12 Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat Powell, Anna L Hindley, Emma Nelson, Andrew JD Davies, Moira Amin, Eman Aggleton, John P Vann, Seralynne D Brain Neurosci Adv Research Paper The retrosplenial cortex forms part of a network of cortical and subcortical structures that have particular importance for spatial learning and navigation in rodents. This study examined how retrosplenial lesions affect activity in this network by visualising the expression of the immediate-early genes c-fos and zif268 after exposure to a novel location. Groups of rats with extensive cytotoxic lesions (areas 29 and 30) and rats with lesions largely confined to area 30 (dysgranular cortex) were compared with their respective control animals for levels of c-fos expression measured by immunohistochemistry. These cortical lesions had very limited effects on distal c-fos activity. Evidence of a restricted reduction in c-fos activity was seen in the septal dentate gyrus (superior blade) but not in other hippocampal and parahippocampal subareas, nor in the anterior cingulate and prelimbic cortices. Related studies examined zif268 activity in those cases with combined area 29 and 30 lesions. The only clear evidence for reduced zif268 activity following retrosplenial cell loss came from the septal CA3 area. The confined impact of retrosplenial tissue loss is notable as, by the same immediate-early gene measures, retrosplenial cortex is itself highly sensitive to damage in related limbic areas, showing a marked c-fos and zif268 hypoactivity across all of its subareas. This asymmetry in covert pathology may help to explain the apparent disparity between the severity of learning deficits after retrosplenial cortex lesions and after lesions in either the hippocampus or the anterior thalamic nuclei. SAGE Publications 2018-11-13 /pmc/articles/PMC7058225/ /pubmed/32166157 http://dx.doi.org/10.1177/2398212818811235 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Paper Powell, Anna L Hindley, Emma Nelson, Andrew JD Davies, Moira Amin, Eman Aggleton, John P Vann, Seralynne D Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
title | Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
title_full | Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
title_fullStr | Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
title_full_unstemmed | Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
title_short | Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
title_sort | lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058225/ https://www.ncbi.nlm.nih.gov/pubmed/32166157 http://dx.doi.org/10.1177/2398212818811235 |
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