Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production

The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic patients. Although the mechanisms for this remain unclear, the prevention of AKI in diabetic nephropathy is feasible and of value. As we detected highly activation of TGF-β/Smad3 signaling in both human biopsy an...

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Detalles Bibliográficos
Autores principales: Wang, Jia-Nan, Yang, Qin, Yang, Chen, Cai, Yu-Ting, Xing, Tian, Gao, Li, Wang, Fang, Chen, Xin, Liu, Xue-Qi, He, Xiao-Yan, Wei, Biao, Jiang, Ling, Li, Chao, Jin, Juan, Wen, Jia-Gen, Ma, Tao-Tao, Chen, Hai-Yong, Li, Jun, Meng, Xiao-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058410/
https://www.ncbi.nlm.nih.gov/pubmed/32143149
http://dx.doi.org/10.1016/j.redox.2020.101479

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