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Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies
Skeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provide...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058629/ https://www.ncbi.nlm.nih.gov/pubmed/32184725 http://dx.doi.org/10.3389/fphar.2020.00142 |
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author | Ahmad, Khurshid Shaikh, Sibhghatulla Ahmad, Syed Sayeed Lee, Eun Ju Choi, Inho |
author_facet | Ahmad, Khurshid Shaikh, Sibhghatulla Ahmad, Syed Sayeed Lee, Eun Ju Choi, Inho |
author_sort | Ahmad, Khurshid |
collection | PubMed |
description | Skeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provides structural support, and plays a vital role during myogenesis. Several human diseases are coupled with dysfunctions of the ECM, and several ECM components are involved in disease pathologies that affect almost all organ systems. Thus, mutations in ECM genes that encode proteins and their transmembrane receptors can result in diverse SM diseases, a large proportion of which are types of fibrosis and muscular dystrophy. In this review, we present major ECM components of SMs related to muscle-associated diseases, and discuss two major ECM myopathies, namely, collagen myopathy and laminin myopathies, and their therapeutic managements. A comprehensive understanding of the mechanisms underlying these ECM-related myopathies would undoubtedly aid the discovery of novel treatments for these devastating diseases. |
format | Online Article Text |
id | pubmed-7058629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70586292020-03-17 Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies Ahmad, Khurshid Shaikh, Sibhghatulla Ahmad, Syed Sayeed Lee, Eun Ju Choi, Inho Front Pharmacol Pharmacology Skeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provides structural support, and plays a vital role during myogenesis. Several human diseases are coupled with dysfunctions of the ECM, and several ECM components are involved in disease pathologies that affect almost all organ systems. Thus, mutations in ECM genes that encode proteins and their transmembrane receptors can result in diverse SM diseases, a large proportion of which are types of fibrosis and muscular dystrophy. In this review, we present major ECM components of SMs related to muscle-associated diseases, and discuss two major ECM myopathies, namely, collagen myopathy and laminin myopathies, and their therapeutic managements. A comprehensive understanding of the mechanisms underlying these ECM-related myopathies would undoubtedly aid the discovery of novel treatments for these devastating diseases. Frontiers Media S.A. 2020-02-28 /pmc/articles/PMC7058629/ /pubmed/32184725 http://dx.doi.org/10.3389/fphar.2020.00142 Text en Copyright © 2020 Ahmad, Shaikh, Ahmad, Lee and Choi http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ahmad, Khurshid Shaikh, Sibhghatulla Ahmad, Syed Sayeed Lee, Eun Ju Choi, Inho Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
title | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
title_full | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
title_fullStr | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
title_full_unstemmed | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
title_short | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
title_sort | cross-talk between extracellular matrix and skeletal muscle: implications for myopathies |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058629/ https://www.ncbi.nlm.nih.gov/pubmed/32184725 http://dx.doi.org/10.3389/fphar.2020.00142 |
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