The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective

Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (...

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Autores principales: Mammadzada, Parviz, Corredoira, Pablo M., André, Helder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058677/
https://www.ncbi.nlm.nih.gov/pubmed/31893312
http://dx.doi.org/10.1007/s00018-019-03422-9
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author Mammadzada, Parviz
Corredoira, Pablo M.
André, Helder
author_facet Mammadzada, Parviz
Corredoira, Pablo M.
André, Helder
author_sort Mammadzada, Parviz
collection PubMed
description Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple growth factors and cytokines involved in angiogenesis and inflammation, hallmarks of nAMD. This knowledge has propelled the development of a new group of therapeutic strategies focused on gene therapy. The present review provides an update on current gene therapies in ocular angiogenesis, particularly nAMD, from both basic and clinical perspectives.
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spelling pubmed-70586772020-03-16 The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective Mammadzada, Parviz Corredoira, Pablo M. André, Helder Cell Mol Life Sci Review Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple growth factors and cytokines involved in angiogenesis and inflammation, hallmarks of nAMD. This knowledge has propelled the development of a new group of therapeutic strategies focused on gene therapy. The present review provides an update on current gene therapies in ocular angiogenesis, particularly nAMD, from both basic and clinical perspectives. Springer International Publishing 2019-12-31 2020 /pmc/articles/PMC7058677/ /pubmed/31893312 http://dx.doi.org/10.1007/s00018-019-03422-9 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Mammadzada, Parviz
Corredoira, Pablo M.
André, Helder
The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
title The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
title_full The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
title_fullStr The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
title_full_unstemmed The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
title_short The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
title_sort role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058677/
https://www.ncbi.nlm.nih.gov/pubmed/31893312
http://dx.doi.org/10.1007/s00018-019-03422-9
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