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Defining microbial biomarkers for risk of preterm labor
Preterm birth remains the main contributor to early childhood mortality. The vaginal environment, including microbiota composition, might contribute to the risk of preterm delivery. Alterations in the vaginal microbial community structure might represent a risk factor for preterm birth. Here, we aim...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058777/ https://www.ncbi.nlm.nih.gov/pubmed/31332740 http://dx.doi.org/10.1007/s42770-019-00118-x |
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author | de Freitas, Anderson Santos Dobbler, Priscila Caroline Thiago Mai, Volker Procianoy, Renato S Silveira, Rita C. Corso, Andréa Lúcia Roesch, Luiz Fernando Wurdig |
author_facet | de Freitas, Anderson Santos Dobbler, Priscila Caroline Thiago Mai, Volker Procianoy, Renato S Silveira, Rita C. Corso, Andréa Lúcia Roesch, Luiz Fernando Wurdig |
author_sort | de Freitas, Anderson Santos |
collection | PubMed |
description | Preterm birth remains the main contributor to early childhood mortality. The vaginal environment, including microbiota composition, might contribute to the risk of preterm delivery. Alterations in the vaginal microbial community structure might represent a risk factor for preterm birth. Here, we aimed to (a) investigate the association between preterm birth and the vaginal microbial community and (b) identify microbial biomarkers for risk of preterm birth. Microbial DNA was isolated from vaginal swabs in a cohort of 69 women enrolled at hospital admission for their delivery. Microbiota was analyzed by high-throughput 16S rRNA sequencing. While no differences in microbial diversity measures appeared associated with the spontaneous preterm and full-term outcomes, the microbial composition was distinct for these groups. Differential abundance analysis showed Lactobacillus species to be associated with full-term birth whereas an unknown Prevotella species was more abundant in the spontaneous preterm group. Although we studied a very miscegenated population from Brazil, our findings were similar to evidence pointed by other studies in different countries. The role of Lactobacillus species as a protector in the vaginal microbiome is demonstrated to be also a protector of spontaneous preterm outcome whereas the presence of pathogenic species, such as Prevotella spp., is endorsed as a factor of risk for spontaneous preterm delivery. |
format | Online Article Text |
id | pubmed-7058777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-70587772020-03-17 Defining microbial biomarkers for risk of preterm labor de Freitas, Anderson Santos Dobbler, Priscila Caroline Thiago Mai, Volker Procianoy, Renato S Silveira, Rita C. Corso, Andréa Lúcia Roesch, Luiz Fernando Wurdig Braz J Microbiol Clinical Microbiology - Research Paper Preterm birth remains the main contributor to early childhood mortality. The vaginal environment, including microbiota composition, might contribute to the risk of preterm delivery. Alterations in the vaginal microbial community structure might represent a risk factor for preterm birth. Here, we aimed to (a) investigate the association between preterm birth and the vaginal microbial community and (b) identify microbial biomarkers for risk of preterm birth. Microbial DNA was isolated from vaginal swabs in a cohort of 69 women enrolled at hospital admission for their delivery. Microbiota was analyzed by high-throughput 16S rRNA sequencing. While no differences in microbial diversity measures appeared associated with the spontaneous preterm and full-term outcomes, the microbial composition was distinct for these groups. Differential abundance analysis showed Lactobacillus species to be associated with full-term birth whereas an unknown Prevotella species was more abundant in the spontaneous preterm group. Although we studied a very miscegenated population from Brazil, our findings were similar to evidence pointed by other studies in different countries. The role of Lactobacillus species as a protector in the vaginal microbiome is demonstrated to be also a protector of spontaneous preterm outcome whereas the presence of pathogenic species, such as Prevotella spp., is endorsed as a factor of risk for spontaneous preterm delivery. Springer International Publishing 2019-07-22 /pmc/articles/PMC7058777/ /pubmed/31332740 http://dx.doi.org/10.1007/s42770-019-00118-x Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Clinical Microbiology - Research Paper de Freitas, Anderson Santos Dobbler, Priscila Caroline Thiago Mai, Volker Procianoy, Renato S Silveira, Rita C. Corso, Andréa Lúcia Roesch, Luiz Fernando Wurdig Defining microbial biomarkers for risk of preterm labor |
title | Defining microbial biomarkers for risk of preterm labor |
title_full | Defining microbial biomarkers for risk of preterm labor |
title_fullStr | Defining microbial biomarkers for risk of preterm labor |
title_full_unstemmed | Defining microbial biomarkers for risk of preterm labor |
title_short | Defining microbial biomarkers for risk of preterm labor |
title_sort | defining microbial biomarkers for risk of preterm labor |
topic | Clinical Microbiology - Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058777/ https://www.ncbi.nlm.nih.gov/pubmed/31332740 http://dx.doi.org/10.1007/s42770-019-00118-x |
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