Cargando…

Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways

Whether smoking-associated DNA methylation has a causal effect on lung function has not been thoroughly evaluated. We first investigated the causal effects of 474 smoking-associated CpGs on forced expiratory volume in 1 s (FEV(1)) in UK Biobank (n = 321,047) by using two-sample Mendelian randomizati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jamieson, Emily, Korologou-Linden, Roxanna, Wootton, Robyn E., Guyatt, Anna L., Battram, Thomas, Burrows, Kimberley, Gaunt, Tom R., Tobin, Martin D., Munafò, Marcus, Davey Smith, George, Tilling, Kate, Relton, Caroline, Richardson, Tom G., Richmond, Rebecca C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058834/ https://www.ncbi.nlm.nih.gov/pubmed/32084330 http://dx.doi.org/10.1016/j.ajhg.2020.01.015

Ejemplares similares

Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization
por: Jones, Daniel P, et al.
Publicado: (2020)

Examining the possible causal relationship between lung function, COPD and Alzheimer’s disease: a Mendelian randomisation study
por: Higbee, Daniel, et al.
Publicado: (2021)

Multi-omics analyses of cognitive traits and psychiatric disorders highlight brain-dependent mechanisms
por: Korologou-Linden, Roxanna, et al.
Publicado: (2021)

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study
por: Taylor, Amy E, et al.
Publicado: (2019)

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging
por: Millard, Louise A. C., et al.
Publicado: (2019)

Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
por: Wootton, Robyn E., et al.
Publicado: (2020)

Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes
por: Reed, Zoe E., et al.
Publicado: (2021)

Cigarette smoking and personality: interrogating causality using Mendelian randomisation
por: Sallis, Hannah M., et al.
Publicado: (2019)

Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization
por: Millard, Louise A. C., et al.
Publicado: (2019)

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
por: Taylor, Kurt, et al.
Publicado: (2019)

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization
por: Sanderson, Eleanor, et al.
Publicado: (2022)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Richardson, Tom G., et al.
Publicado: (2020)

Proxy gene-by-environment Mendelian randomization study of the association between cigarette smoking during pregnancy and offspring mental health
por: Sallis, Hannah M, et al.
Publicado: (2023)

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
por: Morales Berstein, Fernanda, et al.
Publicado: (2022)

Educational inequality in multimorbidity: causality and causal pathways. A mendelian randomisation study in UK Biobank
por: North, Teri-Louise, et al.
Publicado: (2023)

Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer
por: Wade, Kaitlin H., et al.
Publicado: (2022)

Little evidence for an effect of smoking on multiple sclerosis risk: A Mendelian Randomization study
por: Mitchell, Ruth E., et al.
Publicado: (2020)

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk
por: Richardson, Tom G., et al.
Publicado: (2017)

Causal effects of circulating cytokine concentrations on risk of Alzheimer’s disease and cognitive function
por: Pagoni, Panagiota, et al.
Publicado: (2022)

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease
por: Pagoni, Panagiota, et al.
Publicado: (2022)

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomisation study
por: Zheng, Jie, et al.
Publicado: (2022)

Characterizing the Causal Pathway for Genetic Variants Associated with Neurological Phenotypes Using Human Brain-Derived Proteome Data
por: Kibinge, Nelson K., et al.
Publicado: (2020)

Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study
por: Lawn, Rebecca B, et al.
Publicado: (2018)

Epigenome-wide association study of asthma and wheeze in childhood and adolescence
por: Arathimos, Ryan, et al.
Publicado: (2017)

Maternal smoking during pregnancy and autism: using causal inference methods in a birth cohort study
por: Caramaschi, Doretta, et al.
Publicado: (2018)

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease
por: Richardson, Tom G, et al.
Publicado: (2018)

Does smoking cause lower educational attainment and general cognitive ability? Triangulation of causal evidence using multiple study designs
por: Gage, Suzanne H., et al.
Publicado: (2022)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
por: Cho, Yoonsu, et al.
Publicado: (2020)

Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization
por: Gage, Suzanne H., et al.
Publicado: (2017)

USING MENDELIAN RANDOMISATION TO INFER CAUSALITY IN DEPRESSION AND ANXIETY RESEARCH
por: Gage, Suzanne H, et al.
Publicado: (2014)

A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
por: Battram, Thomas, et al.
Publicado: (2022)

Smoking Is Associated with, but Does Not Cause, Depressed Mood in Pregnancy – A Mendelian Randomization Study
por: Lewis, Sarah J., et al.
Publicado: (2011)

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
por: Fang, Si, et al.
Publicado: (2022)

Examining the effect of smoking on suicidal ideation and attempts: triangulation of epidemiological approaches
por: Harrison, Ruth, et al.
Publicado: (2020)

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization
por: Treur, Jorien L., et al.
Publicado: (2019)

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease
por: McGowan, Lucy M, et al.
Publicado: (2019)

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study
por: Richardson, Tom G, et al.
Publicado: (2020)

Assessing causal relationships using genetic proxies for exposures: an introduction to Mendelian randomization
por: Katikireddi, Srinivasa Vittal, et al.
Publicado: (2017)

Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study
por: Richmond, Rebecca C, et al.
Publicado: (2019)

The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses
por: Rasheed, Humaira, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fi0d6649tf4930r3h01pe7hqq8