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The effect of autopolyploidy on population genetic signals of hard sweeps

Searching for population genomic signals left behind by positive selection is a major focus of evolutionary biology, particularly as sequencing technologies develop and costs decline. The effect of the number of chromosome copies (i.e. ploidy) on the manifestation of these signals remains an outstan...

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Autores principales: Monnahan, Patrick, Brandvain, Yaniv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058959/
https://www.ncbi.nlm.nih.gov/pubmed/32097595
http://dx.doi.org/10.1098/rsbl.2019.0796
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author Monnahan, Patrick
Brandvain, Yaniv
author_facet Monnahan, Patrick
Brandvain, Yaniv
author_sort Monnahan, Patrick
collection PubMed
description Searching for population genomic signals left behind by positive selection is a major focus of evolutionary biology, particularly as sequencing technologies develop and costs decline. The effect of the number of chromosome copies (i.e. ploidy) on the manifestation of these signals remains an outstanding question, despite a wide appreciation of ploidy being a fundamental parameter governing numerous biological processes. We clarify the principal forces governing the differential manifestation and persistence of the selection signal by separating the effects of polyploidy on the rates of fixation versus rates of diversity (i.e. mutation and recombination) using coalescent simulations. We explore the major consequences of polyploidy, finding a more localized signal, greater dependence on dominance and longer persistence of the signal following fixation, and discuss what this means for within- and across ploidy inference on the strength and prevalence of selective sweeps. As genomic advances continue to open doors for interrogating natural systems, simulations such as this aid our ability to interpret and compare data across ploidy levels.
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spelling pubmed-70589592020-03-19 The effect of autopolyploidy on population genetic signals of hard sweeps Monnahan, Patrick Brandvain, Yaniv Biol Lett Population Genetics Searching for population genomic signals left behind by positive selection is a major focus of evolutionary biology, particularly as sequencing technologies develop and costs decline. The effect of the number of chromosome copies (i.e. ploidy) on the manifestation of these signals remains an outstanding question, despite a wide appreciation of ploidy being a fundamental parameter governing numerous biological processes. We clarify the principal forces governing the differential manifestation and persistence of the selection signal by separating the effects of polyploidy on the rates of fixation versus rates of diversity (i.e. mutation and recombination) using coalescent simulations. We explore the major consequences of polyploidy, finding a more localized signal, greater dependence on dominance and longer persistence of the signal following fixation, and discuss what this means for within- and across ploidy inference on the strength and prevalence of selective sweeps. As genomic advances continue to open doors for interrogating natural systems, simulations such as this aid our ability to interpret and compare data across ploidy levels. The Royal Society 2020-02 2020-02-26 /pmc/articles/PMC7058959/ /pubmed/32097595 http://dx.doi.org/10.1098/rsbl.2019.0796 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Population Genetics
Monnahan, Patrick
Brandvain, Yaniv
The effect of autopolyploidy on population genetic signals of hard sweeps
title The effect of autopolyploidy on population genetic signals of hard sweeps
title_full The effect of autopolyploidy on population genetic signals of hard sweeps
title_fullStr The effect of autopolyploidy on population genetic signals of hard sweeps
title_full_unstemmed The effect of autopolyploidy on population genetic signals of hard sweeps
title_short The effect of autopolyploidy on population genetic signals of hard sweeps
title_sort effect of autopolyploidy on population genetic signals of hard sweeps
topic Population Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058959/
https://www.ncbi.nlm.nih.gov/pubmed/32097595
http://dx.doi.org/10.1098/rsbl.2019.0796
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