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The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be broadly divided in two classes: single-domain ‘sho...

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Detalles Bibliográficos
Autores principales:	Takada, Hiraku, Roghanian, Mohammad, Murina, Victoriia, Dzhygyr, Ievgen, Murayama, Rikinori, Akanuma, Genki, Atkinson, Gemma C., Garcia-Pino, Abel, Hauryliuk, Vasili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058999/ https://www.ncbi.nlm.nih.gov/pubmed/32184768 http://dx.doi.org/10.3389/fmicb.2020.00277

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