Acquisition of chromosome instability is a mechanism to evade oncogene addiction

Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using a CIN model of Kras‐driven breast cancer, we demonstrate t...

Descripción completa

Detalles Bibliográficos
Autores principales: Salgueiro, Lorena, Buccitelli, Christopher, Rowald, Konstantina, Somogyi, Kalman, Kandala, Sridhar, Korbel, Jan O, Sotillo, Rocio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059010/
https://www.ncbi.nlm.nih.gov/pubmed/32030896
http://dx.doi.org/10.15252/emmm.201910941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059010/
https://www.ncbi.nlm.nih.gov/pubmed/32030896
http://dx.doi.org/10.15252/emmm.201910941

Ejemplares similares