In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneo...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamzian, Nima, Hashemi, Maryam, Ghorbani, Mahdi, Aledavood, Seyed Amir, Ramezani, Mohammad, Bahreyni Toosi, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059059/
https://www.ncbi.nlm.nih.gov/pubmed/32184839
http://dx.doi.org/10.22037/ijpr.2019.14050.12131
_version_ 1783503971351003136
author Hamzian, Nima
Hashemi, Maryam
Ghorbani, Mahdi
Aledavood, Seyed Amir
Ramezani, Mohammad
Bahreyni Toosi, Mohammad Hossein
author_facet Hamzian, Nima
Hashemi, Maryam
Ghorbani, Mahdi
Aledavood, Seyed Amir
Ramezani, Mohammad
Bahreyni Toosi, Mohammad Hossein
author_sort Hamzian, Nima
collection PubMed
description This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system. The physicochemical characteristics of the nanoparticles (NPs) were studied. The dose enhancement ratio (DER) of various treatment groups was calculated and compared using human breast cancer cell line (MCF-7). The DER for PLGA-SPION-Gem was the highest at 1 Gy(60)Co (3.18). Cumulative effect from simultaneous use of two radiosensitizer (Gem and SPIONs) was observed. Thus, we have successfully developed PLGA NPs loaded with gemcitabine and SPIONas a radiosensitizersystem which potentially could be used in radiotherapy.
format Online
Article
Text
id pubmed-7059059
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-70590592020-03-17 In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy Hamzian, Nima Hashemi, Maryam Ghorbani, Mahdi Aledavood, Seyed Amir Ramezani, Mohammad Bahreyni Toosi, Mohammad Hossein Iran J Pharm Res Original Article This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system. The physicochemical characteristics of the nanoparticles (NPs) were studied. The dose enhancement ratio (DER) of various treatment groups was calculated and compared using human breast cancer cell line (MCF-7). The DER for PLGA-SPION-Gem was the highest at 1 Gy(60)Co (3.18). Cumulative effect from simultaneous use of two radiosensitizer (Gem and SPIONs) was observed. Thus, we have successfully developed PLGA NPs loaded with gemcitabine and SPIONas a radiosensitizersystem which potentially could be used in radiotherapy. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC7059059/ /pubmed/32184839 http://dx.doi.org/10.22037/ijpr.2019.14050.12131 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hamzian, Nima
Hashemi, Maryam
Ghorbani, Mahdi
Aledavood, Seyed Amir
Ramezani, Mohammad
Bahreyni Toosi, Mohammad Hossein
In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy
title In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy
title_full In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy
title_fullStr In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy
title_full_unstemmed In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy
title_short In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy
title_sort in-vitro study of multifunctional plga-spion nanoparticles loaded with gemcitabine as radiosensitizer used in radiotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059059/
https://www.ncbi.nlm.nih.gov/pubmed/32184839
http://dx.doi.org/10.22037/ijpr.2019.14050.12131
work_keys_str_mv AT hamziannima invitrostudyofmultifunctionalplgaspionnanoparticlesloadedwithgemcitabineasradiosensitizerusedinradiotherapy
AT hashemimaryam invitrostudyofmultifunctionalplgaspionnanoparticlesloadedwithgemcitabineasradiosensitizerusedinradiotherapy
AT ghorbanimahdi invitrostudyofmultifunctionalplgaspionnanoparticlesloadedwithgemcitabineasradiosensitizerusedinradiotherapy
AT aledavoodseyedamir invitrostudyofmultifunctionalplgaspionnanoparticlesloadedwithgemcitabineasradiosensitizerusedinradiotherapy
AT ramezanimohammad invitrostudyofmultifunctionalplgaspionnanoparticlesloadedwithgemcitabineasradiosensitizerusedinradiotherapy
AT bahreynitoosimohammadhossein invitrostudyofmultifunctionalplgaspionnanoparticlesloadedwithgemcitabineasradiosensitizerusedinradiotherapy

Ejemplares similares