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A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8(+) T Cells in Head and Neck Cancer
The limited ability of cytotoxic CD8(+) T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca(2+)-dependent signaling events control the activity of T cells and are implicated in the failure of imm...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059094/ https://www.ncbi.nlm.nih.gov/pubmed/32184726 http://dx.doi.org/10.3389/fphar.2020.00143 |