Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma

Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here p...

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Autores principales: Kubasch, Anne Sophie, Franke, Georg-Nikolaus, Aldaoud, Ali, Weibl, Konstantin, Jentzsch, Madlen, Sabri, Osama, Horny, Hans-Peter, Fend, Falko, Behre, Gerhard, Platzbecker, Uwe, Vucinic, Vladan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059127/
https://www.ncbi.nlm.nih.gov/pubmed/32181155
http://dx.doi.org/10.3389/fonc.2020.00219
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author Kubasch, Anne Sophie
Franke, Georg-Nikolaus
Aldaoud, Ali
Weibl, Konstantin
Jentzsch, Madlen
Sabri, Osama
Horny, Hans-Peter
Fend, Falko
Behre, Gerhard
Platzbecker, Uwe
Vucinic, Vladan
author_facet Kubasch, Anne Sophie
Franke, Georg-Nikolaus
Aldaoud, Ali
Weibl, Konstantin
Jentzsch, Madlen
Sabri, Osama
Horny, Hans-Peter
Fend, Falko
Behre, Gerhard
Platzbecker, Uwe
Vucinic, Vladan
author_sort Kubasch, Anne Sophie
collection PubMed
description Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here presented first report about successful allogeneic hematopoietic stem cell transplantation leading to remission in a case of tonsillar MCS represents a promising potential curative treatment option for this rare and often fatal disease.
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spelling pubmed-70591272020-03-16 Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma Kubasch, Anne Sophie Franke, Georg-Nikolaus Aldaoud, Ali Weibl, Konstantin Jentzsch, Madlen Sabri, Osama Horny, Hans-Peter Fend, Falko Behre, Gerhard Platzbecker, Uwe Vucinic, Vladan Front Oncol Oncology Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here presented first report about successful allogeneic hematopoietic stem cell transplantation leading to remission in a case of tonsillar MCS represents a promising potential curative treatment option for this rare and often fatal disease. Frontiers Media S.A. 2020-02-28 /pmc/articles/PMC7059127/ /pubmed/32181155 http://dx.doi.org/10.3389/fonc.2020.00219 Text en Copyright © 2020 Kubasch, Franke, Aldaoud, Weibl, Jentzsch, Sabri, Horny, Fend, Behre, Platzbecker and Vucinic. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kubasch, Anne Sophie
Franke, Georg-Nikolaus
Aldaoud, Ali
Weibl, Konstantin
Jentzsch, Madlen
Sabri, Osama
Horny, Hans-Peter
Fend, Falko
Behre, Gerhard
Platzbecker, Uwe
Vucinic, Vladan
Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
title Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
title_full Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
title_fullStr Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
title_full_unstemmed Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
title_short Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
title_sort allogeneic hematopoietic stem cell transplantation in a rare case of tonsillar mast cell sarcoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059127/
https://www.ncbi.nlm.nih.gov/pubmed/32181155
http://dx.doi.org/10.3389/fonc.2020.00219
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