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A high‐fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice

Mammalian sirtuin 6 (SIRT6) is involved in the regulation of many essential processes, especially metabolic homeostasis. SIRT6 knockout mice undergo premature aging and die at age ~4 weeks. Severe glycometabolic disorders have been found in SIRT6 knockout mice, and whether a dietary intervention can...

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Detalles Bibliográficos
Autores principales:	Li, Zhongchi, Xu, Kang, Guo, Yannan, Ping, Lu, Gao, Yuqi, Qiu, Ying, Ni, Jianquan, Liu, Qingfei, Wang, Zhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059164/ https://www.ncbi.nlm.nih.gov/pubmed/31967391 http://dx.doi.org/10.1111/acel.13104

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