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Modulation of hERG K(+) Channel Deactivation by Voltage Sensor Relaxation

The hERG (human-ether-à-go-go-related gene) channel underlies the rapid delayed rectifier current, I(kr), in the heart, which is essential for normal cardiac electrical activity and rhythm. Slow deactivation is one of the hallmark features of the unusual gating characteristics of hERG channels, and...

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Detalles Bibliográficos
Autores principales:	Shi, Yu Patrick, Thouta, Samrat, Claydon, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059196/ https://www.ncbi.nlm.nih.gov/pubmed/32184724 http://dx.doi.org/10.3389/fphar.2020.00139

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