Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery

Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of glucose homeostasis and lipid metabolism, and an important target for the development of modern anti-diabetic drugs. However, current PPARγ-targeting anti-diabetic drugs such as classical thiazolidinediones (TZDs) are associa...

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Detalles Bibliográficos
Autores principales: Jiang, Haowen, Zhou, X. Edward, Shi, Jingjing, Zhou, Zhi, Zhao, Guanguan, Zhang, Xinwen, Sun, Yili, Suino-Powell, Kelly, Ma, Lei, Gao, Hui, Yu, Xiyong, Li, Jia, Li, Jingya, Melcher, Karsten, Xu, H. Eric, Yi, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059199/
https://www.ncbi.nlm.nih.gov/pubmed/32190280
http://dx.doi.org/10.1039/c9sc05487a

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