Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes

OBJECTIVE: Glucagon receptor (GCGR) blockage improves glycemic control and increases circulating glucagon-like peptide-1 (GLP-1) level in diabetic animals and humans. The elevated GLP-1 has been reported to be involved in the hypoglycemic effect of GCGR blockage. However, the source of this elevatio...

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Detalles Bibliográficos
Autores principales: Lang, Shan, Yang, Jin, Yang, Kun, Gu, Liangbiao, Cui, Xiaona, Wei, Tianjiao, Liu, Junling, Le, Yunyi, Wang, Haining, Wei, Rui, Hong, Tianpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Emerging Technologies, Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059498/
https://www.ncbi.nlm.nih.gov/pubmed/32139602
http://dx.doi.org/10.1136/bmjdrc-2019-001025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059498/
https://www.ncbi.nlm.nih.gov/pubmed/32139602
http://dx.doi.org/10.1136/bmjdrc-2019-001025

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