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Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic lupus erythematosus. Compound C (also known as...

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Detalles Bibliográficos
Autores principales:	Lai, Junzhong, Luo, Xuan, Tian, Shuoran, Zhang, Xing, Huang, Shanlu, Wang, Hanze, Li, Qiumei, Cai, Shaoli, Chen, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059800/ https://www.ncbi.nlm.nih.gov/pubmed/32180716 http://dx.doi.org/10.3389/fphar.2020.00088

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