Cargando…
Advanced paternal age directly impacts mouse embryonic placental imprinting
The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and preterm birth. Similar associations have been...
Autores principales: | Denomme, Michelle M., Parks, Jason C., McCallie, Blair R., McCubbin, Nathan I., Schoolcraft, William B., Katz-Jaffe, Mandy G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059926/ https://www.ncbi.nlm.nih.gov/pubmed/32142542 http://dx.doi.org/10.1371/journal.pone.0229904 |
Ejemplares similares
-
Epigenetic Dysregulation Observed in Monosomy Blastocysts Further Compromises Developmental Potential
por: Denomme, Michelle M., et al.
Publicado: (2016) -
The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders
por: Denomme, Michelle M., et al.
Publicado: (2020) -
Compromised global embryonic transcriptome associated with advanced maternal age
por: McCallie, Blair R., et al.
Publicado: (2019) -
Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and Oocyte
por: Katz-Jaffe, Mandy G., et al.
Publicado: (2020) -
Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential
por: McCallie, Blair R., et al.
Publicado: (2016)