Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

The currently approved treatment for female pattern hair loss (FPHL) includes topical minoxidil administration; however, this treatment fails to achieve hair regrowth in some patients. Finasteride, a selective 5α-reductase inhibitor (5-ARI), may be considered as an alternative treatment. However, be...

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Autores principales: Iamsumang, Wimolsiri, Leerunyakul, Kanchana, Suchonwanit, Poonkiat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060023/
https://www.ncbi.nlm.nih.gov/pubmed/32184564
http://dx.doi.org/10.2147/DDDT.S240615
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author Iamsumang, Wimolsiri
Leerunyakul, Kanchana
Suchonwanit, Poonkiat
author_facet Iamsumang, Wimolsiri
Leerunyakul, Kanchana
Suchonwanit, Poonkiat
author_sort Iamsumang, Wimolsiri
collection PubMed
description The currently approved treatment for female pattern hair loss (FPHL) includes topical minoxidil administration; however, this treatment fails to achieve hair regrowth in some patients. Finasteride, a selective 5α-reductase inhibitor (5-ARI), may be considered as an alternative treatment. However, because of its potential teratogenic effects, clinical studies and use of finasteride for FPHL are limited. In this review, we aim to summarize the literature regarding the pharmacology, clinical efficacy, and adverse effects of oral finasteride for the treatment of FPHL and to provide novel therapeutic options including topical finasteride and dutasteride, a new generation 5-ARI, for the treatment of FPHL.
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spelling pubmed-70600232020-03-17 Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date Iamsumang, Wimolsiri Leerunyakul, Kanchana Suchonwanit, Poonkiat Drug Des Devel Ther Review The currently approved treatment for female pattern hair loss (FPHL) includes topical minoxidil administration; however, this treatment fails to achieve hair regrowth in some patients. Finasteride, a selective 5α-reductase inhibitor (5-ARI), may be considered as an alternative treatment. However, because of its potential teratogenic effects, clinical studies and use of finasteride for FPHL are limited. In this review, we aim to summarize the literature regarding the pharmacology, clinical efficacy, and adverse effects of oral finasteride for the treatment of FPHL and to provide novel therapeutic options including topical finasteride and dutasteride, a new generation 5-ARI, for the treatment of FPHL. Dove 2020-03-02 /pmc/articles/PMC7060023/ /pubmed/32184564 http://dx.doi.org/10.2147/DDDT.S240615 Text en © 2020 Iamsumang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Iamsumang, Wimolsiri
Leerunyakul, Kanchana
Suchonwanit, Poonkiat
Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_full Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_fullStr Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_full_unstemmed Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_short Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_sort finasteride and its potential for the treatment of female pattern hair loss: evidence to date
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060023/
https://www.ncbi.nlm.nih.gov/pubmed/32184564
http://dx.doi.org/10.2147/DDDT.S240615
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