Lipid availability determines skeletal progenitor cell fate via SOX9

The avascular nature of cartilage makes it a unique tissue(1–4), but whether and how the absence of nutrient supply regulates chondrogenesis remains unknown. Here, we show that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal proge...

Descripción completa

Detalles Bibliográficos
Autores principales: van Gastel, Nick, Stegen, Steve, Eelen, Guy, Schoors, Sandra, Carlier, Aurélie, Daniëls, Veerle W., Baryawno, Ninib, Przybylski, Dariusz, Depypere, Maarten, Stiers, Pieter-Jan, Lambrechts, Dennis, Van Looveren, Riet, Torrekens, Sophie, Sharda, Azeem, Agostinis, Patrizia, Lambrechts, Diether, Maes, Frederik, Swinnen, Johan V., Geris, Liesbet, Van Oosterwyck, Hans, Thienpont, Bernard, Carmeliet, Peter, Scadden, David T., Carmeliet, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060079/
https://www.ncbi.nlm.nih.gov/pubmed/32103177
http://dx.doi.org/10.1038/s41586-020-2050-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060079/
https://www.ncbi.nlm.nih.gov/pubmed/32103177
http://dx.doi.org/10.1038/s41586-020-2050-1

Ejemplares similares