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Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

Adhesion G protein-coupled receptors (aGPCR) are characterized by a large extracellular region containing a conserved GPCR-autoproteolysis-inducing (GAIN) domain. Despite their relevance to several disease conditions, we do not understand the molecular mechanism by which aGPCRs are physiologically a...

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Detalles Bibliográficos
Autores principales:	Huang, Bill X., Hu, Xin, Kwon, Heung-Sun, Fu, Cheng, Lee, Ji-Won, Southall, Noel, Marugan, Juan, Kim, Hee-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060178/ https://www.ncbi.nlm.nih.gov/pubmed/32144388 http://dx.doi.org/10.1038/s42003-020-0831-6

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