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Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel cause cystic fibrosis. Chaperones, including HSC70, DNAJA1 and DNAJA2, play key roles in both the folding and degradation of wild-type and mutant CFTR at multiple cellular locations. DNAJA1 and HSC70 promote the fold...

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Detalles Bibliográficos
Autores principales:	Baaklini, Imad, Gonçalves, Conrado de Campos, Lukacs, Gergely L., Young, Jason C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060200/ https://www.ncbi.nlm.nih.gov/pubmed/32144307 http://dx.doi.org/10.1038/s41598-020-61107-x

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