Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin

Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unk...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Alweddi, Sally, Struglics, André, Rolfson, Ola, Björkman, Lena I., Kalamajski, Sebastian, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G., Eisler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060204/
https://www.ncbi.nlm.nih.gov/pubmed/32144329
http://dx.doi.org/10.1038/s41598-020-61161-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060204/
https://www.ncbi.nlm.nih.gov/pubmed/32144329
http://dx.doi.org/10.1038/s41598-020-61161-5

Ejemplares similares