Treatment and Prognosis of Radiation-Associated Breast Angiosarcoma in a Nationwide Population

BACKGROUND: Radiation-associated angiosarcoma of the breast (RAASB) is an aggressive malignancy that is increasing in incidence. Only a few previous population-based studies have reported the results of RAASB treatment. METHODS: A search for RAASB patients was carried out in the Finnish Cancer Regis...

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Detalles Bibliográficos
Autores principales: Salminen, Samuli H., Wiklund, Tom, Sampo, Mika M., Tarkkanen, Maija, Pulliainen, Lea, Böhling, Tom O., Tukiainen, Erkki, Hukkinen, Katja, Blomqvist, Carl P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Breast Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060227/
https://www.ncbi.nlm.nih.gov/pubmed/31773514
http://dx.doi.org/10.1245/s10434-019-08085-1
Descripción
Sumario:BACKGROUND: Radiation-associated angiosarcoma of the breast (RAASB) is an aggressive malignancy that is increasing in incidence. Only a few previous population-based studies have reported the results of RAASB treatment. METHODS: A search for RAASB patients was carried out in the Finnish Cancer Registry, and treatment data were collected to identify prognostic factors for survival. RESULTS: Overall, 50 RAASB patients were identified. The median follow-up time was 5.4 years (range 0.4–15.6), and the 5-year overall survival rate was 69%. Forty-seven (94%) patients were operated on with curative intent. Among these patients, the 5-year local recurrence-free survival, distant recurrence-free survival, and overall survival rates were 62%, 75%, and 74%, respectively. A larger planned surgical margin was associated with improved survival. CONCLUSIONS: We found that the majority of RAASB patients were eligible for radical surgical management in this population-based analysis. With radical surgery, the prognosis is relatively good.

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