Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile evolvability. However, HA antigenic site B, which has become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily constrained by its involvement in receptor binding. Here, we employ deep mutational sc...

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Detalles Bibliográficos
Autores principales: Wu, Nicholas C., Otwinowski, Jakub, Thompson, Andrew J., Nycholat, Corwin M., Nourmohammad, Armita, Wilson, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060233/
https://www.ncbi.nlm.nih.gov/pubmed/32144244
http://dx.doi.org/10.1038/s41467-020-15102-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060233/
https://www.ncbi.nlm.nih.gov/pubmed/32144244
http://dx.doi.org/10.1038/s41467-020-15102-5

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