Combination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma

Neurofibromatosis type 2 (NF2) is an inherited disorder characterized by bilateral vestibular schwannomas (VS) that arise from neoplastic Schwann cells (SCs). NF2-associated VSs are often accompanied by meningioma (MN), and the majority of NF2 patients show loss of the NF2 tumor suppressor. mTORC1 a...

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Detalles Bibliográficos
Autores principales: Sagers, Jessica E., Beauchamp, Roberta L., Zhang, Yanling, Vasilijic, Sasa, Wu, Limeng, DeSouza, Patrick, Seist, Richard, Zhou, Wenjianlong, Xu, Lei, Ramesh, Vijaya, Stankovic, Konstantina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060236/
https://www.ncbi.nlm.nih.gov/pubmed/32144278
http://dx.doi.org/10.1038/s41598-020-60156-6

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