FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493

Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues....

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Detalles Bibliográficos
Autores principales: Jiang, Ying, Zhou, Chunlei, Gao, Qiang, Yin, Zhi-Qi, Wang, Jingwen, Mu, Hong, Yan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060423/
https://www.ncbi.nlm.nih.gov/pubmed/32184824
http://dx.doi.org/10.1155/2020/2518297
Descripción
Sumario:Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues. Overexpression of FAM64A resulted in promoting tumor proliferation, migration, and invasion. The miR-493 targeted and negatively regulated FAM64A. Our data showed that upregulation of FAM64A in OS correlated with poor prognosis.

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