FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493

Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues....

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Detalles Bibliográficos
Autores principales: Jiang, Ying, Zhou, Chunlei, Gao, Qiang, Yin, Zhi-Qi, Wang, Jingwen, Mu, Hong, Yan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060423/
https://www.ncbi.nlm.nih.gov/pubmed/32184824
http://dx.doi.org/10.1155/2020/2518297
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author Jiang, Ying
Zhou, Chunlei
Gao, Qiang
Yin, Zhi-Qi
Wang, Jingwen
Mu, Hong
Yan, Jun
author_facet Jiang, Ying
Zhou, Chunlei
Gao, Qiang
Yin, Zhi-Qi
Wang, Jingwen
Mu, Hong
Yan, Jun
author_sort Jiang, Ying
collection PubMed
description Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues. Overexpression of FAM64A resulted in promoting tumor proliferation, migration, and invasion. The miR-493 targeted and negatively regulated FAM64A. Our data showed that upregulation of FAM64A in OS correlated with poor prognosis.
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spelling pubmed-70604232020-03-17 FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493 Jiang, Ying Zhou, Chunlei Gao, Qiang Yin, Zhi-Qi Wang, Jingwen Mu, Hong Yan, Jun J Oncol Research Article Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues. Overexpression of FAM64A resulted in promoting tumor proliferation, migration, and invasion. The miR-493 targeted and negatively regulated FAM64A. Our data showed that upregulation of FAM64A in OS correlated with poor prognosis. Hindawi 2020-02-24 /pmc/articles/PMC7060423/ /pubmed/32184824 http://dx.doi.org/10.1155/2020/2518297 Text en Copyright © 2020 Ying Jiang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Ying
Zhou, Chunlei
Gao, Qiang
Yin, Zhi-Qi
Wang, Jingwen
Mu, Hong
Yan, Jun
FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493
title FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493
title_full FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493
title_fullStr FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493
title_full_unstemmed FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493
title_short FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493
title_sort fam64a promotes osteosarcoma cell growth and metastasis and is mediated by mir-493
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060423/
https://www.ncbi.nlm.nih.gov/pubmed/32184824
http://dx.doi.org/10.1155/2020/2518297
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