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Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy

Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effec...

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Detalles Bibliográficos
Autores principales: Cruz-Whitley, Jessica, Giehl, Nolan, Jen, Kuang-Yu, Young, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060432/
https://www.ncbi.nlm.nih.gov/pubmed/32257470
http://dx.doi.org/10.1155/2020/2638283
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author Cruz-Whitley, Jessica
Giehl, Nolan
Jen, Kuang-Yu
Young, Brian
author_facet Cruz-Whitley, Jessica
Giehl, Nolan
Jen, Kuang-Yu
Young, Brian
author_sort Cruz-Whitley, Jessica
collection PubMed
description Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis. We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma. Subsequent renal biopsy revealed membranoproliferative glomerulonephritis (MPGN). We believe this represents the first reported direct case of nivolumab-associated MPGN. As immunotherapy becomes more widely used in cancer treatment, particular attention must be paid to possible consequences of immune checkpoint inhibitors.
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spelling pubmed-70604322020-04-01 Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy Cruz-Whitley, Jessica Giehl, Nolan Jen, Kuang-Yu Young, Brian Case Rep Nephrol Case Report Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis. We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma. Subsequent renal biopsy revealed membranoproliferative glomerulonephritis (MPGN). We believe this represents the first reported direct case of nivolumab-associated MPGN. As immunotherapy becomes more widely used in cancer treatment, particular attention must be paid to possible consequences of immune checkpoint inhibitors. Hindawi 2020-02-24 /pmc/articles/PMC7060432/ /pubmed/32257470 http://dx.doi.org/10.1155/2020/2638283 Text en Copyright © 2020 Jessica Cruz-Whitley et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cruz-Whitley, Jessica
Giehl, Nolan
Jen, Kuang-Yu
Young, Brian
Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
title Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
title_full Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
title_fullStr Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
title_full_unstemmed Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
title_short Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
title_sort membranoproliferative glomerulonephritis associated with nivolumab therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060432/
https://www.ncbi.nlm.nih.gov/pubmed/32257470
http://dx.doi.org/10.1155/2020/2638283
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