Dual antivascular function of human fibulin‐3 variant, a potential new drug discovery strategy for glioblastoma

The ECM protein EFEMP1 (fibulin‐3) is associated with all types of solid tumor through its cell context‐dependent dual function. A variant of fibulin‐3 was engineered by truncation and mutation to alleviate its oncogenic function, specifically the proinvasive role in glioblastoma multiforme (GBM) ce...

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Detalles Bibliográficos
Autores principales: Ke, Chao, Luo, Jun‐ran, Cen, Zi‐wen, Li, Yanyan, Cai, Hai‐ping, Wang, Jing, Chen, Fu‐rong, Siegel, Eric R., Le, Kody N., Winokan, Jesica R., Gibson, Grace J., McSwain, Asia E., Afrasiabi, Kambiz, Linskey, Mark E., Zhou, You‐Xin, Chen, Zhong‐ping, Zhou, Yi‐Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060460/
https://www.ncbi.nlm.nih.gov/pubmed/31922633
http://dx.doi.org/10.1111/cas.14300

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