Caspase-1 as a regulatory molecule of lipid metabolism

Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In...

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Autores principales: Molla, Meseret Derbew, Ayelign, Birhanu, Dessie, Gashaw, Geto, Zeleke, Admasu, Tesfahun Dessale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060649/
https://www.ncbi.nlm.nih.gov/pubmed/32143623
http://dx.doi.org/10.1186/s12944-020-01220-y
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author Molla, Meseret Derbew
Ayelign, Birhanu
Dessie, Gashaw
Geto, Zeleke
Admasu, Tesfahun Dessale
author_facet Molla, Meseret Derbew
Ayelign, Birhanu
Dessie, Gashaw
Geto, Zeleke
Admasu, Tesfahun Dessale
author_sort Molla, Meseret Derbew
collection PubMed
description Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.
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spelling pubmed-70606492020-03-11 Caspase-1 as a regulatory molecule of lipid metabolism Molla, Meseret Derbew Ayelign, Birhanu Dessie, Gashaw Geto, Zeleke Admasu, Tesfahun Dessale Lipids Health Dis Review Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation. BioMed Central 2020-03-06 /pmc/articles/PMC7060649/ /pubmed/32143623 http://dx.doi.org/10.1186/s12944-020-01220-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Molla, Meseret Derbew
Ayelign, Birhanu
Dessie, Gashaw
Geto, Zeleke
Admasu, Tesfahun Dessale
Caspase-1 as a regulatory molecule of lipid metabolism
title Caspase-1 as a regulatory molecule of lipid metabolism
title_full Caspase-1 as a regulatory molecule of lipid metabolism
title_fullStr Caspase-1 as a regulatory molecule of lipid metabolism
title_full_unstemmed Caspase-1 as a regulatory molecule of lipid metabolism
title_short Caspase-1 as a regulatory molecule of lipid metabolism
title_sort caspase-1 as a regulatory molecule of lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060649/
https://www.ncbi.nlm.nih.gov/pubmed/32143623
http://dx.doi.org/10.1186/s12944-020-01220-y
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