GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone

Growth and differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related transforming growth factor β (TGF-β) family members, but their biological functions are quite distinct. While MSTN has been widely shown to inhibit muscle growth, GDF11 regulates skeletal patterning and organ devel...

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Detalles Bibliográficos
Autores principales: Suh, Joonho, Kim, Na-Kyung, Lee, Seung-Hoon, Eom, Je-Hyun, Lee, Youngkyun, Park, Joo-Cheol, Woo, Kyung Mi, Baek, Jeong-Hwa, Kim, Jung-Eun, Ryoo, Hyun-Mo, Lee, Se-Jin, Lee, Yun-Sil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060712/
https://www.ncbi.nlm.nih.gov/pubmed/32071240
http://dx.doi.org/10.1073/pnas.1916034117

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