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On the evolution of protein–adenine binding

Proteins’ interactions with ancient ligands may reveal how molecular recognition emerged and evolved. We explore how proteins recognize adenine: a planar rigid fragment found in the most common and ancient ligands. We have developed a computational pipeline that extracts protein–adenine complexes fr...

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Detalles Bibliográficos
Autores principales: Narunsky, Aya, Kessel, Amit, Solan, Ron, Alva, Vikram, Kolodny, Rachel, Ben-Tal, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060716/
https://www.ncbi.nlm.nih.gov/pubmed/32079721
http://dx.doi.org/10.1073/pnas.1911349117