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High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients
TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between TXLNA and tumorigenesis and progression of pancreatic adenocarc...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060861/ https://www.ncbi.nlm.nih.gov/pubmed/32185195 http://dx.doi.org/10.1155/2020/2585862 |
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author | Lv, Shuangyu Zhang, Guosen Xie, Longxiang Yan, Zhongyi Wang, Qiang Li, Yongqiang Zhang, Lu Han, Yali Li, Huimin Du, Yaowu Yang, Yanjie Guo, Xiangqian |
author_facet | Lv, Shuangyu Zhang, Guosen Xie, Longxiang Yan, Zhongyi Wang, Qiang Li, Yongqiang Zhang, Lu Han, Yali Li, Huimin Du, Yaowu Yang, Yanjie Guo, Xiangqian |
author_sort | Lv, Shuangyu |
collection | PubMed |
description | TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between TXLNA and tumorigenesis and progression of pancreatic adenocarcinoma (PAAD) is still unclear. The present study was designed to examine the expression profile of TXLNA and explore its prognostic significance in PAAD patients and the possible molecular regulatory mechanism by analyzing a series of data from databases, including GEPIA, LOGpc, STRING, and GeneMANIA. The results indicate that TXLNA mRNA and protein were remarkably increased in PAAD tissues compared with normal pancreatic tissues. The high TXLNA expression was significantly correlated with superior overall survival (OS), disease-free interval (DFI), disease specific survival (DSS), and progression-free interval (PFI) for PAAD patients. In summary, high TXLNA expression could predict favourable OS, DFI, DSS, and PFI for PAAD patients, and it might be as potential prognostic biomarkers and targets for PAAD. |
format | Online Article Text |
id | pubmed-7060861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70608612020-03-17 High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients Lv, Shuangyu Zhang, Guosen Xie, Longxiang Yan, Zhongyi Wang, Qiang Li, Yongqiang Zhang, Lu Han, Yali Li, Huimin Du, Yaowu Yang, Yanjie Guo, Xiangqian Biomed Res Int Research Article TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between TXLNA and tumorigenesis and progression of pancreatic adenocarcinoma (PAAD) is still unclear. The present study was designed to examine the expression profile of TXLNA and explore its prognostic significance in PAAD patients and the possible molecular regulatory mechanism by analyzing a series of data from databases, including GEPIA, LOGpc, STRING, and GeneMANIA. The results indicate that TXLNA mRNA and protein were remarkably increased in PAAD tissues compared with normal pancreatic tissues. The high TXLNA expression was significantly correlated with superior overall survival (OS), disease-free interval (DFI), disease specific survival (DSS), and progression-free interval (PFI) for PAAD patients. In summary, high TXLNA expression could predict favourable OS, DFI, DSS, and PFI for PAAD patients, and it might be as potential prognostic biomarkers and targets for PAAD. Hindawi 2020-02-25 /pmc/articles/PMC7060861/ /pubmed/32185195 http://dx.doi.org/10.1155/2020/2585862 Text en Copyright © 2020 Shuangyu Lv et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lv, Shuangyu Zhang, Guosen Xie, Longxiang Yan, Zhongyi Wang, Qiang Li, Yongqiang Zhang, Lu Han, Yali Li, Huimin Du, Yaowu Yang, Yanjie Guo, Xiangqian High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients |
title | High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients |
title_full | High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients |
title_fullStr | High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients |
title_full_unstemmed | High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients |
title_short | High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients |
title_sort | high txlna expression predicts favourable outcome for pancreatic adenocarcinoma patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060861/ https://www.ncbi.nlm.nih.gov/pubmed/32185195 http://dx.doi.org/10.1155/2020/2585862 |
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